Possible IGem or SynBioLabbings@RP Projects
1.lactoDinosaurBarista
2. and OMVS(Oh my *... Vesicles)
I was thinking of possible IGEM projects when i thought of 2 reallyGood Ideas.
Idea 1 lactoDinosaurBarista:
I thought of the first idea when making coffee. I made my coffee and took out a carton of milk, the carton seemed what you would call bloated with air. Save for the possibility of getting sick , it sucks to have to make another cup of coffee, anyways the milk dident't taste sour, but tasted strongly of butter anyways. This got me thinking tho , what if we could make Bacteria that would detect when the milk is spoiling and then in response produce antimicrobial peptides(AMPS) and other compounds to suppress the growth of other Bacteria, SVCE_Chennai IGEM made antimicrobial peptides for milk that would be produced in response to a change in temperature using an RNA thermometer.
Our bacteria would additionally respond to an imminent spoilage event or increase in Bacteria load produce a Flavour, or Metabolize the milk to make it flavoured. (I was thinking Milo Dinosaur Meat Flavored)
This project seems easy enough as we would be able to build on past IGEM projects and if Time , Resources , Neural Processing power permits we could work on novel ways of making the
Milk taste like MiloDinosaur
MeatThe lactobacillus in our Milk detect an imminent spoilage event;Eg Bacteria Load, Quorum Sensing, Bacteria Clock, Thermometer.
Get our lactobacillus to out compete the "bad" bacteria in the milk. By producing Antimicrobial Peptides, and change the pH of the Milk or grow faster;etc. (Or alternatively produce an odour or color that would indicate the milk is spoiled or spoiling)
Idea 2 OMV and Cell free Biosensor Research:
We could alternatively work on Outer Membrane Vesicles (OMVs) .OMVs from my rough impression are vesicles or "bubbles" surrounded by a Phospholipid Bilayer, inside the OMVs could be useful Molecules or DNA and outside it could be ligands for Bio-signalling. "OMVs are used for the export of Bio-molecules from the cell "
Iam not sure if this would be an IGEM project but we could Look though the literature and IGEM Wikis and work on a proof of concept Cell produced Cell Free OMV , that can persist well in the enviroment. Outer membrane vesicles has been adressed by previous IGEM teams Paris , Cornell and more recently UNSW. Any School Labbing non IGEM project on OMVs would prepare us to win GOLD Smthing at IGEM by training us in the realms of Biochemistry , MCB and Synthetic Biology.
OMVs , from what i understand may potentially function well as a good and reliable Cell Free Chassis or System , We could look into its ability to not degrade and allow molecules in it to persist well in the enviroment or potential benefits of OMVs ,Mechenisms behind its export, packaging of molecules and formation . From there we could come out with possible Applications for OMVs , that would guide a SynBio Project on utilizing OMVs or Research into making better OMVs.
OMVs have many applications , i chanced upon it when thinking of how to make teacher's idea work.
OMVs seem like a good canidate for Teacher's research Idea, we could spread OMV as a subsitute for bacteria and will complement the USB biosensor Idea
- OMVs have the potential in the realm of Biosensors , In-Vivo and we could use them to track biological systems In-Vivo .
- It has great potential in terms of Biomedical research, eg Delivery of Oncologic Drugs.
- OMVs Reaserch has the potential to advance Synthetic Biology Foundationally and will allow us to decouple a life from Synthetic Biology. allowing Synthetic Biology to fufill regulatory requirements in countries and the Body where Bacteria can trigger a frightful shock. OMVs could allow us to develop "Mothership" E-coli factories that produce Cell free OMV Systems without the disandvantages of Being alive
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| Star Craft Carrier and OMVs |
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| Taken From UNSW_Australia IGEM Wiki , TorA-Pal complex is associated with outer membrane vesicles. |
